Phosphodiesterase 3A and Arterial Hypertension
نویسندگان
چکیده
منابع مشابه
New hope for Nutlin-3a therapy for pulmonary arterial hypertension
Pulmonary Arterial Hypertension (PH) is a chronic, progressive, and fatal lung disease characterized by narrowing of pulmonary arteries associated with muscular thickening and intimal proliferation, known as remodeling. If untreated, the 5-year survival rate of PH is 34% (McLaughlin et al., 2002). Unfortunately, there is no systematic strategy established to effectively manage this devastating ...
متن کاملPhosphodiesterase type 5 inhibitors in pulmonary arterial hypertension.
Pulmonary arterial hypertension (PAH) is a rare disease characterized by vascular proliferation and remodeling, resulting in a progressive increase in pulmonary arterial resistance, right heart failure, and death. The pathogenesis of PAH is multifactorial, with endothelial cell dysfunction playing an integral role. This endothelial dysfunction is characterized by an overproduction of vasoconstr...
متن کاملPhosphodiesterase Type 5 Inhibitors for Pulmonary Arterial Hypertension
n engl j med 361;19 nejm.org november 5, 2009 1864 This Journal feature begins with a case vignette that includes a therapeutic recommendation. A discussion of the clinical problem and the mechanism of benefit of this form of therapy follows. Major clinical studies, the clinical use of this therapy, and potential adverse effects are reviewed. Relevant formal guidelines, if they exist, are prese...
متن کاملExpression of Recombinant Phosphodiesterase 3A and 3B Using Baculovirus Expression System
Background: Phosphodiesterase 3A (PDE3A) and phosphodiesterase 3B (PDE3B) play a critical role in the regulation of intracellular level of adenosine 3´,5´-cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3´,5´-cyclic monophosphate (cyclic GMP, cGMP). Subsequently PDE3 inhibitors have shown to relax vascular and inhibit platelet aggregation in cardiovascular disease. Objectives: In th...
متن کاملClinical effects of phosphodiesterase 3A mutations in inherited hypertension with brachydactyly.
Autosomal-dominant hypertension with brachydactyly is a salt-independent Mendelian syndrome caused by activating mutations in the gene encoding phosphodiesterase 3A. These mutations increase the protein kinase A-mediated phosphorylation of phosphodiesterase 3A resulting in enhanced cAMP-hydrolytic affinity and accelerated cell proliferation. The phosphorylated vasodilator-stimulated phosphoprot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation
سال: 2020
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.119.043061